Endocrine Abstracts

Introduction: Pheochromocytomas are catecholamine-producing tumors originated from the chromaffin cells of the adrenal medulla. Although usually sporadic, this tumors could be associated with germline mutations in about 40% of cases. TMEM127 has recently been identified as a novel gene conferring increased susceptibility to pheochromocytoma.Case report: A 42-year-old woman was referred to our Hospital to perform a right adrenalectomy for pheochromocytoma...

Introduction: Dapagliflozin is an oral antidiabetic drug, recently approved for type 2 diabetes and is a sodium-glucose cotransporter type 2 inhibitor (iSGLT2). Its mechanism of action is glycosuria induction, associated with lowering glycemia. The effects of SGLT2 inhibition are insulin-independent, and efficacy is not affected by declining β-cell function or insulin resistance. Additional benefits: weight loss, reduction in blood pressure, lower inciden...

We report the case of a 36 years old female, with personal history of breast cancer, treated with neoadjuvant chemotherapy, breast sectorectomy and then chemotherapy and radiation therapy 2 years ago. She was continuously monitored by her oncologist, disease free for over a year, with recent CT scan that showed no particular lessions suggestive for secondary disease. Meanwhile, she got pregnant and delivered at term a healthy baby. She was admitted 3 months postpartum with int...

Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. Up to 10% of patients develop metastatic lessions and radioiodine resistance. Tirosine kinase inhibitors (TKI) represent a strong therapeutic option for patients with advanced metastatic disease and radioiodine resistance. Sorafenib is the only TKI approved for the treatment of locally advanced or metastatic differentiated radioiodine resistant thyroid carc...

Introduction: Managing diabetes in a child is complex and demanding for parents, for some families this is exacerbated by additional demands. Compromised family capacity may lead to diminished management of a child’s diabetes, increasing the risk for acute and long-term complications. The UK has the highest rates in Europe of children (0-14years) living with Type 1 diabetes (International Diabetes Federation, 2019) however, it is concerning that less than 40% have a HbA1c...

Some patients with type 2 diabetes mellitus (T2DM) suffer from severe insulin resistance (IR). There is still a shortage of research analyzing these patients. Relation between IR and diabetes complications, risk of mortality has been poorly described in patients with T2DM.Objective: To evaluate the prevalence of microvascular and macrovascular complications, mortality in type 2 diabetes patients with severe insulin resistance.Metho...

Introduction: Poorly differentiated thyroid cancer (PDTC) is a rare subtype of thyroid carcinomas, that diagnosis is difficult and often missed in daily routine. It is believed that most of them arise in well-differentiated thyroid carcinoma, although a subset of these lesions apparently also arise de novo.Case report: In 2007, a 55-year-old man had a total thyroidectomy and received radioactive iodine treatment post-surgery due to well-differentiated pa...

Introduction: Prolactin secreting pituitary adenoma represents the most common functioning pituitary neoplasm with a clinical picture that includes amenorrhea, galactorrhea and infertility. Tumor size may vary from microadenomas amendable to medical therapy with dopamine agonists to macroadenomas with difficult management. Complications are usually related to tumor size and most frequently include hypogonadism alone or associated with other pituitary deficiencies, visual field...

Prolactinomas are the most common functional pituitary tumours. Therapy is with dopamine agonists (DA). Cabergoline is frequently used as a first line agent; resistance to therapy is seen to other DA. We present a case of a 32 year old woman who moved to our area in the 1st trimester of pregnancy. She was known to have macroprolactinoma (maximal diameter > 1 cm), impinging on the optic chiasm. She was on cabergoline 0.5 mg once daily, but this was discontinued with no complica...

Objective: Pregnancy in women with type I diabetes mellitus (T1DM) is associated with an increased risk of various obstetric complications. The purpose of this study was to evaluate relation of HbA1c, delivery age and various diabetes aspects on pregnancy outcome and gestation in women with T1DM.Methods: This was a cross-sectional study. A total of 48 women hospitalized to the Hospital of Lithuanian University of Health Sciences Kauno klinikos Endocrinol...